Depends. You should put wild cards to jumps, calls. Anything that will be very likely different. There are other things based on experience but you do fine if you focus on jumps and calls. Just change the address which tells the jump where to jump to, example:
EB 12 13 14
Leave EB where it is because it's just telling you it's a jump following by the jumped range or destination 12 13 14 which can be replaced by wild cards into ** ** ** or ?? ?? ?? whatever sign you prefer.
You need to get some AoB datas (the more, the better). Then you will be able to find a wildcard-pattern. If you want, you can use my tool to auto-generate the best wildcard-pattern:
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