you could always just be careful with what you download and open..
however if you refuse to do that a nice little sandbox would be good for testing apps to make sure they dont mess up your machine, thats what i prefer to do.
apparently avast is a good av,
i stick with avg free with zone alarm, or nod32
you will never get one that meets your requirements there are problems with them all you wont notice until a while of usage.
or if you want supreme security you could always just install linux
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