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DXM does not cause Olney's Lesions in humans

 
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HitIer
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PostPosted: Sat Dec 26, 2015 1:40 am    Post subject: DXM does not cause Olney's Lesions in humans Reply with quote

NCBI dismisses claim that dextromethorphan causes Olney's Lesions.

For an extensive period of time, it was believed that dextromethorphan would lead to lesions in the brain, as with other similar dissociative anesthetics. However, this was later considered inconclusive, due to a lack of a similar study in humans. Now, PubMed has shared information with WebMD from a 2007 study, which says:

"Oral administration of dextromethorphan does not produce neuronal vacuolation in the rat brain...There were no detectable neuropathologic changes following single or repeated oral administration of dextromethorphan at any dose...Thus characteristic neuropathologic changes found with more potent NMDA receptor antagonists do not occur following single or repeated oral administration of dextromethorphan"

This means that, not only is there lack of evidence of the lesions in humans, but also, there was never evidence of the lesions in rats at recreational doses either.

Psychiatrists have long known this, since 2007.

Link:

https://www.ncbi.nlm.nih.gov/pubmed/17573115

Source:

Carliss, R.D.; Radovsky, A.; Chengelis, C.P.; o’Neill, T.P.; Shuey, D.L. (2007). "Oral administration of dextromethorphan does not produce neuronal vacuolation in the rat brain". NeuroToxicology 28 (4): 813–8.

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t328163 wrote:
Your username derives from the fact that this site cannot format special characters lol.


t328163 wrote:

lmfao, on reddit i'd get banned
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TheIndianGuy
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PostPosted: Sat Dec 26, 2015 2:14 am    Post subject: Reply with quote

still neurotoxic to the brain in high doses. people go straight retarded from repeated dxm and pcp use.
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M.
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PostPosted: Sat Dec 26, 2015 9:17 am    Post subject: Reply with quote

TheIndianGuy wrote:
still neurotoxic to the brain in high doses. people go straight retarded from repeated dxm and pcp use.
As demonstrated by OP
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finnegan waking up
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PostPosted: Sat Dec 26, 2015 10:17 am    Post subject: Reply with quote

kept saying this all to some dumb motherfucker on the forum who was criticising me for using dxm and mxe, not like i was abusing them. using those or pretty much any drug will fuck u up eventually
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